| All Time Matchup | KC - 0 || BUF - 2 || 0 ties
Last Game: | | Record | 4-11-0 (0-8-0 Away) |
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| Coach | Gracie Hunt |
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| Off Scheme | WestCoast |
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| Def Scheme | D43 |
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| Offense | Overall - 4937(16) : Pass - 3057(11) : Rush - 1880(15) |
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| Defense | Overall - 5336(11) : Pass - 3223(14) : Rush - 2113(7) |
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| Leading Passer | Vince Young - 1704 |
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| Leading Rusher | Marcus Allen - 1352 |
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| Leading Receiver | Trumaine Johnson - 832 |
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| Leading Tackler | Jon Beason - 166 |
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| Turnovers | 30 Take Aways / 20 Turn Overs (+10) |
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| Penalties | 84 For 766 Yards |
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| | Record | 9-6-0 (6-1-0 Home) |
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| Coach | Marv Levy |
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| Off Scheme | SpreadHybrid |
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| Def Scheme | D43 |
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| Offense | Overall - 5694(2) : Pass - 2472(17) : Rush - 3222(1) |
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| Defense | Overall - 5114(8) : Pass - 2616(5) : Rush - 2498(18) |
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| Leading Passer | Mike Ngo - 1799 |
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| Leading Rusher | Greg Bell - 1633 |
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| Leading Receiver | Andre Reed - 807 |
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| Leading Tackler | Larry Izzo - 104 |
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| Turnovers | 35 Take Aways / 16 Turn Overs (+19) |
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| Penalties | 88 For 766 Yards |
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| Last Game Starters |
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Kansas City Chiefs Offense| Quarterback | Matt Moore |
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| Running Backs | Marcus Allen - Marcus Allen |
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| Receivers | Marcus Allen - Miles Austin |
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| Tight End | Miles Austin |
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| Offensive Line | Daryn Colledge - Daryn Colledge - Jeff Hartings - Daryn Colledge - Cody Risien |
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Kansas City Chiefs Defense
| Defensive Line | Ray Edwards - Ray Edwards - Doug Martin - Dan Hampton |
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| Linebackers | Dan Hampton - Matt Millen - Dan Hampton |
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| Cornerbacks | Gary Green - Leslie Frazier |
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| Safeties | Shaun Gayle - Shaun Gayle |
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| Kicker / Punter | Connor Hughes - Connor Hughes |
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Buffalo Bills Offense| Quarterback | Mike Ngo |
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| Running Backs | Greg Bell - Tuffy Leemans |
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| Receivers | Greg Jennings - Andre Reed |
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| Tight End | Owen Daniels |
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| Offensive Line | Eric Young - Jahri Evans - Nick Mangold - Rich Baldinger - Zach Strief |
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Buffalo Bills Defense
| Defensive Line | Simeon Rice - Russell Maryland - Darryl Grant - Reggie White |
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| Linebackers | John Mobley - Larry Izzo - Chip Banks |
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| Cornerbacks | Louis Wright - Mike Mickens |
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| Safeties | Vince Albritton - James Ihedigbo |
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| Kicker / Punter | Nick Folk - Shayne Edge |
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| Injuries |
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Kansas City Chiefs Injuries
| Ron Solt (G) | Jammed Toe (Probable) |
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| Vince Young (QB) | Broken Foot (Questionable) |
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| Miles Austin (WR) | Fractured Cheekbone (Probable) |
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Buffalo Bills Injuries
| Chip Banks (LB) | Turf Toe (Probable) |
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| Nick Mangold (C) | Scratched Cornea (Probable) |
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| Owen Daniels (TE) | Scratched Cornea (Questionable) |
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| Tuffy Leemans (FB) | Jammed Toe (Probable) |
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| Mike Mickens (CB) | Broken Nose (Probable) |
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