| All Time Matchup | SF - 4 || BUF - 0 || 0 ties
Last Game: | | Record | 9-6-0 (5-3-0 Away) |
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| Coach | Grace Savage |
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| Off Scheme | SpreadHybrid |
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| Def Scheme | D34 |
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| Offense | Overall - 5486(7) : Pass - 3124(10) : Rush - 2362(8) |
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| Defense | Overall - 4933(6) : Pass - 2534(3) : Rush - 2399(15) |
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| Leading Passer | Bernie Kosar - 2206 |
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| Leading Rusher | Joe Morris - 1331 |
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| Leading Receiver | Anthony Carter - 923 |
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| Leading Tackler | Freddie Joe Nunn - 114 |
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| Turnovers | 20 Take Aways / 19 Turn Overs (+1) |
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| Penalties | 82 For 644 Yards |
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| | Record | 9-6-0 (6-1-0 Home) |
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| Coach | Marv Levy |
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| Off Scheme | SpreadHybrid |
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| Def Scheme | D43 |
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| Offense | Overall - 5694(2) : Pass - 2472(17) : Rush - 3222(1) |
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| Defense | Overall - 5114(8) : Pass - 2616(5) : Rush - 2498(18) |
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| Leading Passer | Mike Ngo - 1799 |
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| Leading Rusher | Greg Bell - 1633 |
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| Leading Receiver | Andre Reed - 807 |
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| Leading Tackler | Larry Izzo - 104 |
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| Turnovers | 35 Take Aways / 16 Turn Overs (+19) |
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| Penalties | 88 For 766 Yards |
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| Last Game Starters |
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San Francisco 49ers Offense| Quarterback | Bernie Kosar |
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| Running Backs | Joe Morris - Mike Rozier |
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| Receivers | Jerry Rice - Anthony Carter |
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| Tight End | Steve Jordan |
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| Offensive Line | Willie Anderson - Mike Munchak - Bart Oates - Gene Williams - James Williams |
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San Francisco 49ers Defense
| Defensive Line | Charles Mann - John Jurkovic - Leonard Marshall |
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| Linebackers | Donnie Edwards - Mike Merriweather - Johnny Rembert - Freddie Joe Nunn |
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| Cornerbacks | Frank Minnifield - Ray Horton |
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| Safeties | Wes Hopkins - Dennis Smith |
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| Kicker / Punter | Scott Blanton - Jeff Hayes |
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Buffalo Bills Offense| Quarterback | Mike Ngo |
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| Running Backs | Greg Bell - Tuffy Leemans |
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| Receivers | Greg Jennings - Andre Reed |
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| Tight End | Owen Daniels |
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| Offensive Line | Eric Young - Jahri Evans - Nick Mangold - Rich Baldinger - Zach Strief |
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Buffalo Bills Defense
| Defensive Line | Simeon Rice - Russell Maryland - Darryl Grant - Reggie White |
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| Linebackers | John Mobley - Larry Izzo - Chip Banks |
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| Cornerbacks | Louis Wright - Mike Mickens |
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| Safeties | Vince Albritton - James Ihedigbo |
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| Kicker / Punter | Nick Folk - Shayne Edge |
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| Injuries |
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San Francisco 49ers Injuries
| Jerry Rice (WR) | Jammed Toe (Questionable) |
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| Bernie Kosar (QB) | Broken Foot (Probable) |
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| Brandon Marshall (WR) | Jammed Finger (Probable) |
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Buffalo Bills Injuries
| Chip Banks (LB) | Turf Toe (Probable) |
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| Nick Mangold (C) | Scratched Cornea (Probable) |
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| Owen Daniels (TE) | Scratched Cornea (Questionable) |
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| Tuffy Leemans (FB) | Jammed Toe (Probable) |
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| Mike Mickens (CB) | Broken Nose (Probable) |
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