| All Time Matchup | CHC - 1 || SF - 6 || 0 ties
Last Game: Week 5, 1988 - San Francisco 49ers - 30 @ Chicago Cardinals - 13 | | Record | 0-2-0 (0-2-0 Away) |
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| Coach | Paddy Driscoll |
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| Off Scheme | SpreadHybrid |
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| Def Scheme | D43 |
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| Offense | Overall - 489(20) : Pass - 236(20) : Rush - 253(11) |
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| Defense | Overall - 1094(20) : Pass - 512(15) : Rush - 582(20) |
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| Leading Passer | Neil Lomax - 3282 |
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| Leading Rusher | James Brooks II - 1278 |
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| Leading Receiver | James Lofton - 945 |
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| Leading Tackler | Lawrence Taylor - 222 |
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| Turnovers | 1 Take Aways / 3 Turn Overs (-2) |
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| Penalties | 9 For 68 Yards |
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| | Record | 1-1-0 (1-0-0 Home) |
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| Coach | Grace Savage |
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| Off Scheme | SpreadHybrid |
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| Def Scheme | D34 |
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| Offense | Overall - 644(16) : Pass - 416(13) : Rush - 228(15) |
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| Defense | Overall - 765(13) : Pass - 390(7) : Rush - 375(18) |
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| Leading Passer | Bernie Kosar - 4476 |
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| Leading Rusher | Joe Morris - 1545 |
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| Leading Receiver | Anthony Carter - 1336 |
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| Leading Tackler | Freddie Joe Nunn - 133 |
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| Turnovers | 2 Take Aways / 1 Turn Overs (+1) |
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| Penalties | 9 For 81 Yards |
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| Last Game Starters |
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Chicago Cardinals Offense| Quarterback | Jimmy Conzelman |
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| Running Backs | Joseph Addai - Joshua Ezeudu |
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| Receivers | Willie Davis - Alvin Harper |
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| Tight End | Pete Holohan |
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| Offensive Line | Ken Ruettgers - Gene Williams - Dan Turk - Ken Reeves - Bubba Paris |
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Chicago Cardinals Defense
| Defensive Line | Dexter Manley - Eric Swann - Phillip Daniels - Terrel Bernard |
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| Linebackers | Robert Lyles - Randy Gradishar - Otis Wilson |
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| Cornerbacks | Mike Richardson - Cedric Mack |
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| Safeties | Paul Moyer - Nephi Sewell |
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| Kicker / Punter | Morten Andersen - Morten Andersen |
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San Francisco 49ers Offense| Quarterback | Bernie Kosar |
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| Running Backs | Joe Morris - Mike Rozier |
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| Receivers | Anthony Carter - Jerry Rice |
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| Tight End | Steve Jordan |
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| Offensive Line | Willie Anderson - Mike Munchak - Steve McKinney - Dylan Parham - James Williams |
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San Francisco 49ers Defense
| Defensive Line | Charles Mann - John Jurkovic - Jacob Green |
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| Linebackers | Nik Bonitto - Johnny Rembert - Gary Plummer - Freddie Joe Nunn |
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| Cornerbacks | Frank Minnifield - Ray Horton |
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| Safeties | Reed Blankenship - Dennis Smith |
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| Kicker / Punter | Scott Blanton - Jon Ryan |
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| Injuries |
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Chicago Cardinals Injuries
| Paul Moyer (FS) | Patella Tendinitis (Probable) |
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| Bubba Paris (T) | Bruised Hip (Probable) |
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| Gene Williams (G) | Patella Tendinitis (Probable) |
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| Jimmy Conzelman (QB) | Hernia (Out (1-2 weeks)) |
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| Malik Willis (QB) | Jammed Finger (Probable) |
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| Jim Everett (QB) | Deep Thigh Bruise (Doubtful) |
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San Francisco 49ers Injuries
| Steve Jordan (TE) | Sprained Ankle (Doubtful) |
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| James Williams (T) | Torn Biceps Muscle (Out (12-16 weeks)) |
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