| All Time Matchup | BUF - 2 || SD - 1 || 0 ties
Last Game: Week 17, 1989 - San Diego Chargers - 24 @ Buffalo Bills - 17 | | Record | 3-4-0 (1-1-0 Away) |
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| Coach | Marv Levy |
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| Off Scheme | SpreadHybrid |
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| Def Scheme | D43 |
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| Offense | Overall - 2433(13) : Pass - 1565(10) : Rush - 868(10) |
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| Defense | Overall - 2581(11) : Pass - 1991(17) : Rush - 590(1) |
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| Leading Passer | Mike Ngo - 1163 |
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| Leading Rusher | Greg Bell - 619 |
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| Leading Receiver | Marvin Harrison - 598 |
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| Leading Tackler | Mike Singletary - 52 |
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| Turnovers | 7 Take Aways / 5 Turn Overs (+2) |
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| Penalties | 36 For 310 Yards |
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| | Record | 3-4-0 (2-2-0 Home) |
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| Coach | Holden McGroin |
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| Off Scheme | WestCoast |
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| Def Scheme | D43Hybrid |
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| Offense | Overall - 2654(9) : Pass - 1990(6) : Rush - 664(19) |
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| Defense | Overall - 2754(16) : Pass - 1992(18) : Rush - 762(5) |
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| Leading Passer | Jason Campbell - 1990 |
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| Leading Rusher | Ronnie Harmon - 406 |
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| Leading Receiver | Chris Burkett - 584 |
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| Leading Tackler | Mo Lewis - 69 |
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| Turnovers | 8 Take Aways / 6 Turn Overs (+2) |
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| Penalties | 45 For 362 Yards |
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| Last Game Starters |
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Buffalo Bills Offense| Quarterback | Mike Ngo |
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| Running Backs | Greg Bell - Tuffy Leemans |
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| Receivers | Marvin Harrison - Andre Reed |
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| Tight End | Pete Metzelaars |
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| Offensive Line | Anthony Munoz - Jahri Evans - Nick Mangold - Cam Jurgens - Eric Young |
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Buffalo Bills Defense
| Defensive Line | Reggie White - Russell Maryland - Darryl Grant - Simeon Rice |
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| Linebackers | Pat Swilling - Mike Singletary - Lawrence Taylor |
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| Cornerbacks | Everson Walls - Marcus Jones CB |
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| Safeties | Eugene Robinson - Roland James |
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| Kicker / Punter | Nick Novak - Jake Camarda |
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San Diego Chargers Offense| Quarterback | Jason Campbell |
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| Running Backs | Ronnie Harmon - Michael Robinson |
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| Receivers | Chris Burkett - Garrett Wilson |
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| Tight End | Clint Didier |
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| Offensive Line | Joe Thomas - Kurt Quarterman - Joe Thomas - Rob Sims - Donald Penn |
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San Diego Chargers Defense
| Defensive Line | Darryl Tapp - Orpheus Roye - Charles Haley - Keyunta Dawson |
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| Linebackers | Fredd Young - Mo Lewis - Darren Comeaux |
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| Cornerbacks | Jack Jones - Al Harris |
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| Safeties | JT Woods - Mo Lewis |
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| Kicker / Punter | Tony Franklin - Tony Franklin |
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| Injuries |
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Buffalo Bills Injuries
| Mike Ngo (QB) | Sprained Knee (Probable) |
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| Cam Jurgens (G) | Sprained Wrist (Questionable) |
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San Diego Chargers Injuries
| Rob Sims (G) | Groin Pull (Out (2-4 weeks)) |
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| Kurt Quarterman (G) | Scratched Cornea (Doubtful) |
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