| All Time Matchup | SD - 1 || BUF - 2 || 0 ties
Last Game: Week 17, 1989 - San Diego Chargers - 24 @ Buffalo Bills - 17 | | Record | 4-4-0 (2-2-0 Away) |
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| Coach | Holden McGroin |
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| Off Scheme | WestCoast |
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| Def Scheme | D43Hybrid |
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| Offense | Overall - 3187(6) : Pass - 2216(6) : Rush - 971(11) |
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| Defense | Overall - 3011(14) : Pass - 2180(17) : Rush - 831(5) |
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| Leading Passer | Jason Campbell - 2216 |
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| Leading Rusher | Ronnie Harmon - 578 |
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| Leading Receiver | Chris Burkett - 676 |
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| Leading Tackler | Mo Lewis - 80 |
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| Turnovers | 10 Take Aways / 7 Turn Overs (+3) |
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| Penalties | 50 For 422 Yards |
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| | Record | 4-4-0 (2-3-0 Home) |
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| Coach | Marv Levy |
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| Off Scheme | SpreadHybrid |
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| Def Scheme | D43 |
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| Offense | Overall - 2708(15) : Pass - 1721(11) : Rush - 987(10) |
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| Defense | Overall - 2736(7) : Pass - 2041(15) : Rush - 695(2) |
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| Leading Passer | Mike Ngo - 1193 |
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| Leading Rusher | Greg Bell - 724 |
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| Leading Receiver | Marvin Harrison - 634 |
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| Leading Tackler | Mike Singletary - 64 |
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| Turnovers | 10 Take Aways / 5 Turn Overs (+5) |
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| Penalties | 42 For 360 Yards |
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| Last Game Starters |
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San Diego Chargers Offense| Quarterback | Jason Campbell |
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| Running Backs | Ronnie Harmon - Michael Robinson |
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| Receivers | Chris Burkett - Garrett Wilson |
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| Tight End | Clint Didier |
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| Offensive Line | Joe Thomas - Kurt Quarterman - Joe Thomas - Rob Sims - Donald Penn |
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San Diego Chargers Defense
| Defensive Line | Darryl Tapp - Orpheus Roye - Charles Haley - Keyunta Dawson |
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| Linebackers | Fredd Young - Mo Lewis - Darren Comeaux |
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| Cornerbacks | Jack Jones - Al Harris |
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| Safeties | JT Woods - Mo Lewis |
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| Kicker / Punter | Tony Franklin - Tony Franklin |
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Buffalo Bills Offense| Quarterback | Mike Ngo |
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| Running Backs | Greg Bell - Tuffy Leemans |
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| Receivers | Marvin Harrison - Andre Reed |
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| Tight End | Pete Metzelaars |
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| Offensive Line | Anthony Munoz - Jahri Evans - Nick Mangold - Cam Jurgens - Eric Young |
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Buffalo Bills Defense
| Defensive Line | Reggie White - Russell Maryland - Darryl Grant - Simeon Rice |
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| Linebackers | Pat Swilling - Mike Singletary - Lawrence Taylor |
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| Cornerbacks | Everson Walls - Marcus Jones CB |
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| Safeties | Eugene Robinson - Nick Cross |
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| Kicker / Punter | Nick Novak - Jake Camarda |
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| Injuries |
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San Diego Chargers Injuries
| James Griffin (FS) | Migraine (Questionable) |
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| Rob Sims (G) | Groin Pull (Out (1-2 weeks)) |
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| Kurt Quarterman (G) | Scratched Cornea (Questionable) |
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Buffalo Bills Injuries
| Mike Ngo (QB) | Sprained Wrist (Doubtful) |
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| Cam Jurgens (G) | Sprained Wrist (Probable) |
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