| All Time Matchup | BUF - 2 || SEA - 5 || 0 ties Last Game: Week 21, 1989 - Seattle Seahawks - 27 @ Buffalo Bills - 31 | | Record | 2-0-0 (1-0-0 Away) |
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| Coach | Marv Levy |
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| Off Scheme | SpreadHybrid |
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| Def Scheme | D43 |
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| Offense | Overall - 720(11) : Pass - 486(9) : Rush - 234(14) |
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| Defense | Overall - 769(14) : Pass - 624(18) : Rush - 145(3) |
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| Leading Passer | Mike Ngo - 2953 |
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| Leading Rusher | Greg Bell - 1762 |
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| Leading Receiver | Terry Glenn - 1079 |
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| Leading Tackler | Lawrence Taylor - 145 |
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| Turnovers | 4 Take Aways / 0 Turn Overs (+4) |
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| Penalties | 11 For 100 Yards |
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| | Record | 1-1-0 (0-0-0 Home) |
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| Coach | Johnny Mnemonic |
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| Off Scheme | WestCoastHybrid |
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| Def Scheme | D34Hybrid |
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| Offense | Overall - 788(8) : Pass - 386(15) : Rush - 402(2) |
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| Defense | Overall - 994(19) : Pass - 731(20) : Rush - 263(11) |
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| Leading Passer | Warren Moon - 4294 |
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| Leading Rusher | Jim Brown - 1712 |
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| Leading Receiver | Art Monk - 1249 |
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| Leading Tackler | Kevin Hardy - 165 |
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| Turnovers | 4 Take Aways / 2 Turn Overs (+2) |
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| Penalties | 12 For 125 Yards |
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| Last Game Starters |
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Buffalo Bills Offense| Quarterback | Mike Ngo |
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| Running Backs | Greg Bell - Tuffy Leemans |
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| Receivers | Marvin Harrison - Andre Reed |
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| Tight End | Pete Metzelaars |
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| Offensive Line | Anthony Munoz - Jahri Evans - Nick Mangold - Cam Jurgens - Eric Young |
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Buffalo Bills Defense
| Defensive Line | Reggie White - Russell Maryland - Darryl Grant - Simeon Rice |
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| Linebackers | Pat Swilling - Mike Singletary - Lawrence Taylor |
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| Cornerbacks | Everson Walls - Marcus Jones CB |
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| Safeties | Eugene Robinson - Roland James |
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| Kicker / Punter | Nick Novak - Jake Camarda |
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| Seattle Seahawks Offense| Quarterback | Randall Cunningham |
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| Running Backs | Jim Brown - Matt Suhey |
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| Receivers | Art Monk - Irving Fryar |
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| Tight End | Jay Novacek |
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| Offensive Line | Lance Smith - Dan Fike - Don Mosebar - Marshal Yanda - Lance Smith |
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Seattle Seahawks Defense
| Defensive Line | Elvis Dumervil - Steve McMichael - Mario Williams |
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| Linebackers | Bryan Cox - Kevin Hardy - Clay Matthews - Tamba Hali |
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| Cornerbacks | Trent McDuffie - Wendell Cason |
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| Safeties | LaRon Landry - Donte Whitner |
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| Kicker / Punter | John Kasay - Sean Landeta |
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| Injuries |
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Buffalo Bills Injuries
| Pete Metzelaars (TE) | Torn Miniscus (Out (1-2 weeks)) |
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| Seattle Seahawks Injuries
| Mario Williams (DE) | Jammed Finger (Questionable) |
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| LaRon Landry (FS) | Fractured Leg (Out for the season) |
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