| All Time Matchup | SF - 4 || DET - 4 || 0 ties
Last Game: Week 17, 1990 - Detroit Lions - 35 @ San Francisco 49ers - 42 | | Record | 2-4-0 (0-3-0 Away) |
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| Coach | Grace Savage |
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| Off Scheme | SpreadHybrid |
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| Def Scheme | D34Hybrid |
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| Offense | Overall - 6159(12) : Pass - 3499(11) : Rush - 2660(4) |
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| Defense | Overall - 6374(13) : Pass - 3573(4) : Rush - 2801(19) |
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| Leading Passer | Brock Purdy - 2677 |
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| Leading Rusher | Joe Perry - 1286 |
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| Leading Receiver | Anthony Carter - 879 |
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| Leading Tackler | Dennis Smith - 115 |
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| Turnovers | 18 Take Aways / 16 Turn Overs (+2) |
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| Penalties | 100 For 929 Yards |
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| | Record | 5-1-0 (3-0-0 Home) |
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| Coach | Nick Miller |
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| Off Scheme | SpreadHybrid |
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| Def Scheme | D43Hybrid |
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| Offense | Overall - 6306(11) : Pass - 4570(7) : Rush - 1736(19) |
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| Defense | Overall - 6095(8) : Pass - 4060(11) : Rush - 2035(8) |
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| Leading Passer | John Elway - 4115 |
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| Leading Rusher | Marcus Allen - 936 |
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| Leading Receiver | Mike Williams - 1349 |
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| Leading Tackler | David Harris - 133 |
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| Turnovers | 28 Take Aways / 25 Turn Overs (+3) |
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| Penalties | 109 For 938 Yards |
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| Last Game Starters |
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San Francisco 49ers Offense| Quarterback | Brock Purdy |
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| Running Backs | Joe Perry - Mel Baltazar |
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| Receivers | Brandon Marshall - Jerry Rice |
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| Tight End | Steve Jordan |
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| Offensive Line | Willie Anderson - Mike Munchak - Steve McKinney - Chris Chester - James Williams |
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San Francisco 49ers Defense
| Defensive Line | Charles Mann - John Jurkovic - Sean Jones |
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| Linebackers | Freddie Joe Nunn - Donnie Edwards - Johnny Rembert - Hugh Green |
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| Cornerbacks | Frank Minnifield - Ray Horton |
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| Safeties | Reed Blankenship - Joey Browner |
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| Kicker / Punter | Jeff Wilkins - Jon Ryan |
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Detroit Lions Offense| Quarterback | John Elway |
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| Running Backs | Marcus Allen - James Jones FB II |
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| Receivers | Greg Jennings - Mike Williams |
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| Tight End | Isaiah Likely |
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| Offensive Line | Bruce Matthews - Larry Allen - Gene Chilton - Flozell Adams - Jimbo Covert |
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Detroit Lions Defense
| Defensive Line | Clyde Simmons - Keith Millard - Joe Nash - Tim Harris |
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| Linebackers | Randall Godfrey - David Harris - Duane Bickett |
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| Cornerbacks | R.W. McQuarters - Cam Taylor-Britt |
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| Safeties | Kyle Hamilton - Lawyer Milloy |
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| Kicker / Punter | Matt Stover - Jordan Stout |
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| Injuries |
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San Francisco 49ers Injuries
| Sean Jones (DE) | Dislocated Shoulder (Probable) |
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| Charles Mann (DE) | Tight Hamstring (Questionable) |
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| Freddie Joe Nunn (LB) | Hyper Extended Knee (Doubtful) |
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| Willie Anderson (T) | Tight Hamstring (Probable) |
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Detroit Lions Injuries
| Tim Harris (DE) | Dislocated Finger (Probable) |
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