| All Time Matchup | BUF - 3 || MIN - 2 || 0 ties
Last Game: | | Record | 6-3-0 (3-1-0 Away) |
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| Coach | Marv Levy |
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| Off Scheme | SpreadHybrid |
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| Def Scheme | D43 |
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| Offense | Overall - 6707(6) : Pass - 4477(10) : Rush - 2230(12) |
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| Defense | Overall - 6264(12) : Pass - 4703(20) : Rush - 1561(1) |
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| Leading Passer | Mike Ngo - 1636 |
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| Leading Rusher | Joseph Addai - 629 |
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| Leading Receiver | Sidney Rice - 468 |
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| Leading Tackler | Mike Singletary - 53 |
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| Turnovers | 24 Take Aways / 17 Turn Overs (+7) |
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| Penalties | 115 For 949 Yards |
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| | Record | 4-5-0 (3-1-0 Home) |
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| Coach | Brock Lesnar |
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| Off Scheme | SpreadHybrid |
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| Def Scheme | D34 |
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| Offense | Overall - 6507(8) : Pass - 4520(9) : Rush - 1987(14) |
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| Defense | Overall - 6200(10) : Pass - 4403(14) : Rush - 1797(2) |
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| Leading Passer | Kurt Warner - 1952 |
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| Leading Rusher | Kenneth Walker III - 642 |
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| Leading Receiver | Devin Hester - 483 |
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| Leading Tackler | Alan Page - 71 |
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| Turnovers | 13 Take Aways / 13 Turn Overs (0) |
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| Penalties | 108 For 890 Yards |
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| Last Game Starters |
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Buffalo Bills Offense| Quarterback | Mike Ngo |
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| Running Backs | Joseph Addai - Tuffy Leemans |
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| Receivers | Andre Reed - Sidney Rice |
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| Tight End | Pete Metzelaars |
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| Offensive Line | Winston Justice - Jahri Evans - Nick Mangold - Cam Jurgens - Eric Young |
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Buffalo Bills Defense
| Defensive Line | Leonard Marshall - Russell Maryland - Tony Casillas - Reggie White |
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| Linebackers | Jesse Solomon - Mike Singletary - Pat Swilling |
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| Cornerbacks | Sauce Gardner - Kaiir Elam |
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| Safeties | Eugene Robinson - Rodney Harrison |
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| Kicker / Punter | Nick Novak - Jake Camarda |
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Minnesota Vikings Offense| Quarterback | Kurt Warner |
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| Running Backs | Kenneth Walker III - Craig James |
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| Receivers | Devin Hester - Dwayne Bowe |
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| Tight End | Preston Gothard |
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| Offensive Line | John Alt - Jermane Mayberry - Joel Hilgenberg - Chris Kuper - Chris Hinton |
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Minnesota Vikings Defense
| Defensive Line | Travon Walker - Bryant Young - Keith Willis |
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| Linebackers | Kayvon Thibodeaux - Andre Tippett - Thad Castle - Alan Page |
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| Cornerbacks | Aaron Glenn - Jeff Donaldson |
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| Safeties | Shawn Wooden - Jaquan Brisker |
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| Kicker / Punter | Doug Brien - John Teltschik |
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| Injuries |
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Buffalo Bills Injuries
| Eugene Robinson (FS) | Ruptured Disc (Back) (Out (8-12 weeks)) |
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| Andre Reed (WR) | Fractured Eye Socket (Probable) |
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| Mike Ngo (QB) | Bruised Jaw (Questionable) |
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| Vince Young (QB) | Tight Hamstring (Probable) |
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| Sidney Rice (WR) | Bruised Cheekbone (Probable) |
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| Cam Jurgens (G) | Tight Hamstring (Probable) |
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| London Fletcher (LB) | Deep Thigh Bruise (Probable) |
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| Rodney Harrison (SS) | Bruised Cheekbone (Probable) |
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Minnesota Vikings Injuries
| Dwayne Bowe (WR) | Jammed Toe (Probable) |
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