| All Time Matchup | CHC - 0 || BUF - 2 || 0 ties
Last Game: | | Record | 1-10-0 (0-6-0 Away) |
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| Coach | Paddy Driscoll |
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| Off Scheme | WestCoast |
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| Def Scheme | D43 |
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| Offense | Overall - 4582(20) : Pass - 2795(19) : Rush - 1787(18) |
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| Defense | Overall - 7541(20) : Pass - 4103(12) : Rush - 3438(20) |
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| Leading Passer | Jimmy Conzelman - 1014 |
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| Leading Rusher | Terry Allen - 630 |
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| Leading Receiver | James Jones WR - 663 |
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| Leading Tackler | Terrel Bernard - 68 |
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| Turnovers | 23 Take Aways / 11 Turn Overs (+12) |
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| Penalties | 120 For 893 Yards |
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| | Record | 7-4-0 (4-3-0 Home) |
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| Coach | Marv Levy |
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| Off Scheme | SpreadHybrid |
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| Def Scheme | D43 |
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| Offense | Overall - 6707(6) : Pass - 4477(10) : Rush - 2230(12) |
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| Defense | Overall - 6264(12) : Pass - 4703(20) : Rush - 1561(1) |
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| Leading Passer | Mike Ngo - 1636 |
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| Leading Rusher | Joseph Addai - 773 |
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| Leading Receiver | Sidney Rice - 544 |
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| Leading Tackler | Mike Singletary - 70 |
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| Turnovers | 24 Take Aways / 17 Turn Overs (+7) |
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| Penalties | 115 For 949 Yards |
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|
| Last Game Starters |
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Chicago Cardinals Offense| Quarterback | Jimmy Conzelman |
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| Running Backs | Terry Allen - Willie Colon |
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| Receivers | James Jones WR - Skyy Moore |
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| Tight End | Chigoziem Okonkwo |
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| Offensive Line | Ken Ruettgers - Gene Williams - Kevin Glover - John Rankin - Antone Davis |
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Chicago Cardinals Defense
| Defensive Line | Phillip Daniels - Eric Swann - Larry Roberts - Dexter Manley |
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| Linebackers | Terrel Bernard - Randy Gradishar - Terrel Bernard |
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| Cornerbacks | Mike Richardson - Cortland Finnegan |
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| Safeties | Harry Hamilton - Kenny Easley |
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| Kicker / Punter | Morten Andersen - Morten Andersen |
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Buffalo Bills Offense| Quarterback | Mike Ngo |
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| Running Backs | Joseph Addai - Tuffy Leemans |
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| Receivers | Andre Reed - Sidney Rice |
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| Tight End | Pete Metzelaars |
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| Offensive Line | Winston Justice - Jahri Evans - Nick Mangold - Cam Jurgens - Eric Young |
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Buffalo Bills Defense
| Defensive Line | Frostee Rucker - Russell Maryland - Jim Stillwagon - Simon Fletcher |
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| Linebackers | London Fletcher - Mike Singletary - Pat Swilling |
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| Cornerbacks | Sauce Gardner - Kaiir Elam |
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| Safeties | Eugene Robinson - Rodney Harrison |
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| Kicker / Punter | Nick Novak - Jake Camarda |
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|
| Injuries |
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Chicago Cardinals Injuries
| Dexter Manley (DE) | Bruised Hip (Probable) |
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| Phillip Daniels (DE) | Patella Tendinitis (Probable) |
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| Cortland Finnegan (CB) | Jammed Toe (Probable) |
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| Eric Swann (DT) | Deep Thigh Bruise (Out (1-2 weeks)) |
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| Terry Allen (RB) | Fractured Jaw (Doubtful) |
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| Jimmy Conzelman (QB) | Migraine (Probable) |
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Buffalo Bills Injuries
| Eugene Robinson (FS) | Ruptured Disc (Back) (Out (8-12 weeks)) |
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| Simon Fletcher (DE) | Broken Collarbone (Out (1-2 weeks)) |
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| Mike Ngo (QB) | Bruised Jaw (Probable) |
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| Tony Casillas (DT) | Sprained Knee (Doubtful) |
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